There were no differences between HLV and LLV cases for duration of HIV infection (15 vs. 18 years; P = 0.3), plasma HIV-1 RNA copies at CSF escape (400 vs. 258 copies/mL; P = 0.1), or CD4 nadir (34 vs. 14 cells/mm3; P = 0.7); CD4 cell count was lower in the HLV subgroup (P = 0.04). This evidence concerns the gene CD4 and HIV infectious disease.