Allergen‐induced and IgE‐dependent activation of BA and MC and the consecutive release of vascular and proinflammatory mediators from these cells are key events in allergic reactions.4, 5, 6, 7, 8 However, although several relevant signaling molecules and pathways downstream of the IgER have been identified and many different drugs are available, little is known about the effects of these agents on BA. The gene discussed is IGHE; the disease is allergic disease.