These findings concur with our recent results16 showing that genetic Atgl deficiency causes decreased TG accumulation in WAT due to suppressed PPARγ signalling and suggest that both genetic and pharmacological inhibition of lipolysis lead to resistance to HFD-induced obesity via decreasing food intake and lowering TG synthesis and lipid deposition in WAT. Here, PPARG is linked to obesity due to melanocortin 4 receptor deficiency.