EDCs are compounds with mostly estrogenic activities and considering that recently, natural estrogens have been classified as known human carcinogens [7] it is plausible that EDCs can be considered oncogenic factors.Estrogens can act as potent mitogens in estrogen receptor (ER)-positive cells with continual exposure to an estrogenic stimulus, having the potential to promote DNA instability, cellular hyperplasia and neoplastic transformation of epithelial cells into carcinomas [8]. Here, ESR1 is linked to carcinoma.