Therefore TCDD would induce several AhR-mediated changes in gene expression an tissue-/species-specific toxicities and is a potent inhibitor of estrogen-mediated activity: both tumorigenic and anticarcinogenic responses occur, including inhibition of estrogen-dependent uterine and mammary tumor formation and and growth, via inhibitory AhR–estrogen receptor cross-talk [27,113]. This evidence concerns the gene AHR and breast cancer.