TNF and obesity due to melanocortin 4 receptor deficiency: The treatment with IL-10-conjugated phosphatidylserine-containing liposomes with high affinity for macrophages exhibited significant anti-obesity and anti-inflammatory effects, such as reduced serum total cholesterol, adipocyte size, crown-like structures, pro-inflammatory cytokine secretion (IL-6 and tumor necrosis factor α) in adipose tissue, and liver injury in obese mice [18].