SGLT2 inhibitors, such as canagliflozin, have been shown to provide significant improvements in HbA1c, body weight, and BP in a broad range of patients with T2DM [23], including older patient populations (≥65 and ≥75 years of age) who may be at elevated risk of CV disease [26, 27]. This evidence concerns the gene SLC5A2 and type 2 diabetes mellitus.