The TLE proteins do not bind directly to DNA to exert their repressive effect on gene transcription; instead, they utilise their WDR domains to bind to DNA‐bound transcription factors.1 Given their role in pathways known to be deregulated in many cancers, it is not surprising that members of the TLE family, particularly TLE1, have been implicated in the development and maintenance of malignancies. This evidence concerns the gene TLE1 and cancer.