Consistently, our research found that the frequency of ApoE genotype E2/E2 and APOE E2/E3 in DN group were significantly higher than control group in Chinese T2DM patients and, compared with ApoE ε3 allele carriers, the occurrence of DN in ApoE ε2 allele carriers is about 2.2-fold higher. Here, APOE is linked to type 2 diabetes mellitus.