Therefore, considering that CAA can reduce oxidative stress in human renal proximal tubular cells [17], in the present work, we evaluated different oxidative stress parameters, namely, MDA, lipid hydroperoxides, and GSH/GSSG ratio, as well as the activities of the antioxidant enzymes CAT and GR in homogenates from the kidney of rats subjected to 5/6th nephrectomy, in the hope to contribute to new therapeutic modalities for the treatment of CKD. This evidence concerns the gene GSR and chronic kidney disease.