In addition, AR-catalyzed formation of sorbitol was also observed in a number of tissues and in diabetes mellitus; increased sorbitol through the polyol pathway does not readily diffuse across cell membranes and the intracellular accumulation of sorbitol has been implicated in the chronic complications of diabetes such as cataract, neuropathy, and retinopathy [21]. The gene discussed is AR; the disease is diabetes mellitus.