TMPRSS2 and nonpapillary renal cell carcinoma: Several novel ccRCC TSG candidates (SLC34A2, OVOL1, DLEC1, TMPRSS2, SSTand BMP4) have been found in a global study of CpG methylation in 38 ccRCC and 9 age-matched healthy tissues (~27,500 CpGs and >14,000 genes) (32).