In a multicenter study, Szymanska et al. (20) investigated the correlation between TP53 (exons 5–9), EGFR (exons 18–21) and KRAS (codon 12) mutation and Von Hippel-Lindau (VHL) gene in tissue samples derived from 361 RCC (334 clear-cell carcinomas) patients. This evidence concerns the gene EGFR and clear cell adenocarcinoma.