LRRK1 and osteosclerosis: These skeletal phenotypes of the Plekhm1 mutant patient seem quite different from the patient with an Lrrk1 mutation, and Lrrk1 KO mice that exhibited a severe osteosclerosis confined to the metaphysis of the long and short tubular bones.3,42 Thus, whether LRRK1 regulation of TBC1D2-dependent Rab7 inactivation and autophagy formation plays a critical role in osteoclast function will require further investigation.