SPP1 and osteoporosis: Pyrophosphate upregulates osteopontin, and pyrophosphate and osteopontin together inhibit bone mineralization.34CD36 (collagen type 1 receptor), upregulated in the patient’s osteoblasts, could be involved in the genesis of osteoporosis through stimulation of bone resorption.35 The upregulation of collagen type IV alpha 1 and alpha 2 subunits has been linked to low bone mass.36 Tumor necrosis factor receptor 11B (OPG) mRNA and protein expression were upregulated and by binding to RANKL could lead to unrestrained bone formation.37 Secreted frizzled-related protein 2 (SFRP2) was upregulated.