Surgical and CO2 laser treatments can be used to remove the skin lesions, but the treatment is only temporary and the lesions often return over time.[53,57,59–61] A recent double-blind placebo-controlled randomized split-face study showed no effect of the topical mTOR inhibitor rapamycin on fibrofolliculoma in BHDS patients.[62]. This evidence concerns the gene MTOR and Fibrofolliculoma.