Interestingly, TRAIL presented by MSCT-EVs is more efficient at cancer cell killing than rTRAIL as 100 μg/ml MSCT-EV that contains 3.88 ng TRAIL/ml induced significantly more apoptosis in M231 cells compared with 100 ng/ml of rTRAIL (Figure 4(b)). Here, TNFSF10 is linked to cancer.