BRCA1 and breast cancer: The spatial localization of BRCA1, BRCA2 (Miki et al., 1994; Hofmann and Schlag, 2000), RAD51 (Martin et al., 2007), agrees with the known specificity of these genes to breast cancer, and physical or predicted interactions with each other (Warde-Farley et al., 2010; Zuberi et al., 2013).