TINF2 and multiple sclerosis: For instance, if a patient with a risk score of 112.71 [identified with mutations in CRYAB, a gene associated with multiple sclerosis (Chauhan et al., 2013)] is compared with another patient who has a risk score of 506.11 [with mutations in TINF2, a gene associated with Idiopathic pulmonary fibrosis (Donahoe et al., 2015)], the relative risk of the former to the latter is 0.22 (Table S2, Supplementary Information).