LARS1 and infection: These CLRs bind a broad variety of pathogenic microbial organisms and their polysaccharides (Geijtenbeek and Gringhuis, 2016) such as HIV virus (Geijtenbeek et al., 2000), mycobacteria (Geijtenbeek et al., 2003), C. albicans (Cambi et al., 2003; te Riet et al., 2015), Streptococcus pneumoniae (Kang et al., 2004) or Helicobacter pylori (Bergman et al., 2004) and serve as a target of penetration and infection in the host’s cell while the specific immune response is prevented (van Kooyk et al., 2003).