Our results are consistent with the recent work by Jack et al. (2015) showing no effect of APOE gene alleles on memory and cognitive decline and with previous studies showing no association between APOE ε4 and hippocampal volume in cognitively normal individuals (Jack et al., 1998; Protas et al., 2013; Lupton et al., 2016). This evidence concerns the gene APOE and Mental deterioration.