PPARG and Alzheimer disease: Several studies have demonstrated that PPAR-γ agonists alleviate neuroinflammation in AD models by acting as anti-inflammatory regulators (Ghisletti et al., 2007; Saijo et al., 2013) while others have shown that PPAR-γ can regulate the secretion of inflammatory cytokines in microglia, ultimately promoting tissue repair (Chawla, 2010; Chinetti-Gbaguidi et al., 2011).