Even though we did not present evidence on memory improvement by adiponectin through PPAR-γ in AD brain, we speculate that adiponectin may improve memory in AD by attenuating PPAR-γ signaling in microglia, and regulate the function of microglia under Aβ toxicity by regulating PPAR-γ through AdipoR1. The gene discussed is ADIPOQ; the disease is Alzheimer disease.