Since GABAA signaling (and possibly Cl− homeostasis) has been repeatedly described as a key regulator of sleep and circadian rhythms (Wagner et al., 1997; Choi et al., 2008), it is possible that alterations of GABA signaling and/or expression of NKCC1 may play a role in sleep disorders in DS. This evidence concerns the gene SLC12A2 and Dravet syndrome.