Another direct link between DS genetic triplication and GABA signaling came from the discovery that the KCNJ6 gene, which encodes the subunit 2 of the GIRK channel (GIRK2/Kir3.2), maps to Hsa21 (Ohira et al., 1997; Hattori et al., 2000). This evidence concerns the gene KCNJ6 and Dravet syndrome.