Triplication of GIRK2 is instead unlikely to directly contribute to GABAB-mediated early developmental DS brain alterations, as coupling of GABABRs with GIRK channels does not occur until the second postnatal week of life in rats (Fukuda et al., 1993; López-Bendito et al., 2003; Bony et al., 2013). This evidence concerns the gene KCNJ6 and Dravet syndrome.