KCNJ6 and Anxiety: For example the overexpression of GIRK2 in the midbrain of Ts65Dn mice (Harashima et al., 2006) may modulate signal transduction of dopamine receptors (Perez et al., 2006; Podda et al., 2010; Marcott et al., 2014; Zhao et al., 2016) and impact on different DS phenotypes including anxiety-related symptoms (Sim et al., 2013).