On the other hand, since GIRK2 knockout mice show reduced anxiety-related behavior (Pravetoni and Wickman, 2008) but GABABR knockout mice show an anxious phenotype (Mombereau et al., 2005), coupling of GIRK channels to metabotropic neurotransmitter receptor systems other than GABABRs may play a role in regulating anxiety-related behaviors in DS. Here, KCNJ6 is linked to Anxiety.