Although the general molecular mechanism of GHB action is still matter of debate (Bay et al., 2014; Venzi et al., 2015), it is intriguing to speculate that, in the scenario of GABA dysregulation in DS, both the GABABR-GIRK2 signaling and depolarizing GABAA signaling may play a role in GBL-induced epileptic phenotype seen in Ts65Dn mice. The gene discussed is MLST8; the disease is Dravet syndrome.