Although GHS arrested the hypercholesterolemic effect of dietary cholesterol observed and improved insulin resistance, given by the TyG index in HC animals, this diet negatively affected the delta-6-desaturase-elongase activity and markedly depressed the gene expression of antioxidant enzymes and Ldlr suggesting that caution needs to be taken when incorporating large amounts of glucomannan or glucomannan plus spirulina to cholesterol enriched diets. This evidence concerns the gene FADS2 and Insulin resistance.