E2F1 and neoplasm: The overlap in biological processes, Reactome pathways, and oncogenic signatures that are enriched in CA20- and CIN25-high groups is striking given that the two signatures only share one gene in common (CDK1) and suggests that they reflect relatively similar molecular tumor biology (namely, potential activation of DNA repair pathways, perhaps to cope with DNA damage occurring due to chromosome missegregation, enhanced cell cycle kinetics and microtubule dynamics, and activated E2F1 signaling), although perhaps with subtle but prognostically important qualitative and quantitative distinctions.