Interestingly, a small but significant increase in the number of neuroblasts that migrated to the site of injury was noted following PEG-IGF-I treatment starting at 3 hrs, 1-day and 5-days post-stroke (P < 0.05, P < 0.01, P < 0.01 respectively: Fig. 5F). The gene discussed is IGF1; the disease is stroke disorder.