Synaptophysin expression was assessed 7-days post-stroke following treatment with 1 mg/kg PEG-IGF-I in young animals and shown to be elevated on both ipsilateral (stroke side) and contralateral (non-stroked side) hemispheres following treatment starting from 3 hrs, 1-day and 5-days post-stroke, although results were only significant for the 1-day post-stroke time period. Here, IGF1 is linked to stroke disorder.