IGF1 and Stroke: Dosing at 0.3 mg/kg resulted in a small yet non-significant decrease in infarct volume when dosing started at 3 hrs post-stroke (vehicle, 1.35 ± 0.09 mm3 versus 0.3 mg/kg PEG-IGF-I, 1.07 ± 0.08 mm3, P = 0.051, n = 5 per group; Fig. 2A).