ACTA1 and Hepatic fibrosis: The production of α-SMA, TGF-β1, fibronectin, collagen type I and IV will be down-regulated, meanwhile, the expression of matrix metalloproteinases (MMP) effectively degrading ECM, such as MMP-1 and MMP-3, might be up-regulated, which are beneficial to inhibit hepatic fibrosis procedure22.