ALB and diabetic kidney disease: However, these studies have primarily investigated the renal response to toxins (e.g. high glucose in diabetic nephropathy or high albumin levels to mimic proteinuria), drugs (e.g. acetaminophen) or acute renal injury (e.g. using unilateral ureteric obstruction), or have focused on glomerular injury (Dickhout and Krepinsky, 2009).