UMOD and Renal insufficiency: However, this hypercalcemia in association with raised plasma ALP activity in the Umod125R/125R mice, which has also previously been reported in two ENU-induced mutant mouse models with A227T and C93F Umod mutations (Kemter et al., 2009, 2013) (Table S1), has not been observed to occur in ADTKD-UMOD patients who develop renal failure.