A transgenic mouse model carrying a human UMOD transgene containing the ADTKD-UMOD-causing mutation Cys148Trp (C148W) in addition to the two mouse Umod alleles was not reported to have renal impairment or abnormal renal histology (Takiue et al., 2008a,b) (Table S1). This evidence concerns the gene UMOD and autosomal dominant medullary cystic kidney disease with or without hyperuricemia.