Interestingly, in female Umod125R/125R mice, this decreased uric acid excretion was detected after the onset of renal failure, as measured by a significantly increased plasma urea, since 8-week-old Umod125R/125R females had an elevated plasma urea, but a similar uric acid excretion compared to Umod+/+ females. This evidence concerns the gene UMOD and Renal insufficiency.