However, a second transgenic mouse expressing mouse Umod with the C148W mutation developed several features of ADTKD-UMOD, including mild renal failure, urinary concentrating defects, and interstitial inflammation and fibrosis, but decreased uric acid excretion was not reported (Bernascone et al., 2010) (Table S1). Here, UMOD is linked to autosomal dominant medullary cystic kidney disease with or without hyperuricemia.