UMOD and autosomal dominant medullary cystic kidney disease with or without hyperuricemia: Dual-labeling for uromodulin and the ER marker calnexin showed that the intracellular uromodulin in Umod+/125R and Umod125R/125R kidneys was colocalized with the ER (Fig. 1F), as previously demonstrated both in vitro (Williams et al., 2009) and in ADTKD-UMOD patients (Bernascone et al., 2010), and consistent with the presence of the lower molecular mass precursor detected by western blotting (Fig. 1C).