However, a second transgenic mouse expressing mouse Umod with the C148W mutation developed several features of ADTKD-UMOD, including mild renal failure, urinary concentrating defects, and interstitial inflammation and fibrosis, but decreased uric acid excretion was not reported (Bernascone et al., 2010) (Table S1). The gene discussed is UMOD; the disease is Renal insufficiency.