A plausible explanation for this occurrence of hypercalcemia, likely due to tertiary hyperparathyroidism, in Umod mutant mice but not ADTKD-UMOD patients is that the earlier detection of renal failure and associated secondary hyperparathyroidism, with appropriate treatment using vitamin D analogs, phosphate binders and calcimimetics, will prevent the progression to tertiary hyperparathyroidism in patients. The gene discussed is UMOD; the disease is Hypercalcemia.