Interestingly, TTF-1 gene was a well-known lineage-specific oncogene in lung cancer, which dominantly expressed in lung cancer but not in other types of cancers.20, 21, 22 Therefore, in the present study, we attempted to design and construct an eukaryotic vector encoding miR-7, which was manipulated by the TTF-1 promoter. The gene discussed is TTF1; the disease is cancer.