Dystrophin provides a crucial structural connection among the muscle cytoskeleton, the sarcolemma, and the extracellular matrix to maintain muscle integrity.3, 4 The absence of dystrophin makes myofibers extremely susceptible to injury during muscle contraction, which leads to progressive muscle deterioration and weakness, respiratory insufficiency, cardiac failure, and premature death.5, 6. The gene discussed is DMD; the disease is Respiratory insufficiency.