In C. albicans keratitis, TLR-knockout mice are helpful to determine the effect of TLR2 and 4 in experiment yet, the severity of fungal keratitis in murine mutant strains was similar to that in wild-type control mice, more fungi were recovered after 3 days of infection from TLR2−/− than from TLR4−/− mouse corneas. This evidence concerns the gene TLR4 and keratitis.