In experimental models, pro-inflammatory cytokines such as interleukin-1 (IL-1), IL-6, and tumor necrosis factor-α (TNF) have been shown to play a key role in both anorexia and skeletal muscle proteolysis,28 but the relationships between systemic inflammation and changes in body composition in cancer patients are less well understood. This evidence concerns the gene IL6 and Anorexia.