One limitation of this study is that we were unable to show reproducibility; although leukocytosis and erythrocytosis were not described in a phase II and III trial for lusutrombopag, another TPO agonist, eltrombopag, improved hematopoiesis including hemoglobin and neutrophil counts in patients with aplastic anemia [12]. The gene discussed is TPO; the disease is aplastic anemia.