The resulting aberrant TGF-β superfamilysignaling results in epistaxis, telangiectasia, and arteriovenous malformations.Interestingly, previous histochemical and microscopic examination of endometrial bloodvessels from women with normal and HMB revealed increased endothelial gaps in women withheavy loss (22). This evidence concerns the gene TGFB1 and telangiectasis.