Our study demonstrates thatinsulin treatment prevents oltipraz and Nrf2 stimulation of Agt geneexpression, suggesting that chronic Nrf2 activation by hyperglycemia and/or Nrf2activator(s) may exaggerate renal dysfunction via activation of the intrarenal RAS,thereby enhancing renal fluid and salt reabsorption. This evidence concerns the gene AGT and Hyperglycemia.