We reported previously that catalase (Cat) overexpression in renal proximal tubular cells(RPTCs) prevents hypertension and nephropathy, attenuates renal angiotensinogen(Agt) and Nrf2 gene expression, and blocks Nrf2stimulation of Agt gene transcription, in type 1 diabetes (T1D) AkitaCat-transgenic mice (11–13). Here, AGT is linked to type 1 diabetes mellitus.