Increased PAPP-A concentrations were associated with reduced GDM risk [odds ratio 0.623 (0.453, 0.856), P = 3.5 × 10−3, n = 777] and reduced mean arterial blood pressures (β = −0.202 to −0.177, P = 1.7 to 6.9 × 10−3, n = 347 to 355). The gene discussed is PAPPA; the disease is gestational diabetes.