The systemic fasting plasmaIL-6 concentrations did not change significantly between the control andhypercortisolemia conditions (time point, 0 minutes, 11.7 ± 3.6 pg/mLvs 12.7 ± 6.9 pg/mL; P = 0.798).Abdominal adipose tissue appeared to be a net producer of IL-6 (release control, 12.6± 5.6 pg/mL/100 g tissue; hypercortisolemia, 19.7 ± 9.7 pg/mL/100 gtissue). The gene discussed is IL6; the disease is adrenal gland hyperfunction.