This confirms that substantial cTnI elevations occur significantly more frequently in DM1 patients compared with the manufacturertlycontrol population (p = 0.0007 in two-tailed Fisheril exact test).[21] Echo data were available for five patients with elevated cTnI, of whom three showed LV impairment (one mild, one moderate, one severe), and one mild LV hypertrophy. This evidence concerns the gene TNNI3 and myotonic dystrophy type 1.