In stark contrast to the infection study of M. avium paratuberculosis a pathogen which specifically invades human small intestinal goblet cells, our preliminary data suggest a lack of co-localisation between L. intracellularis bacteria antigen and the goblet cell marker, MUC2 and mucin-containing vacuoles (S2A and S2B Fig) [34]. The gene discussed is MUC5AC; the disease is infection.