PTEN and neoplasm: As we reported here, we observed accelerated oncogenic transformation and aggressive tumor phenotypes in the prostates of Lzts2LoxP/LoxP-PtenloxP/Wt:PB-Cre4 mice with the deletion of both Pten and Lzts2 genes in comparison to PtenloxP/Wt:PB-Cre4 mice with Pten deletion only.