In one such case, a patient with junctional epidermolysis bullosa was found to have two distinct nonsense mutations in the laminin subunit α-3 gene (LAMA3) that were predicted to cause infant mortality in combination (R943X and R1159X; Fig 4A) [37]. The gene discussed is LAMA3; the disease is Junctional epidermolysis bullosa, Herlitz type.