MAPT and Pallister-Hall syndrome: We additionally found that the PHS was associated with worsening CDR-SB score over time (β-coefficient = 2.49, SE = 0.38, p-value = 1.1 × 10−10), decreased CSF Aβ1–42 (reflecting increased intracranial Aβ plaque load) (β-coefficient = −0.07, SE = 0.01, p-value = 1.28 × 10−7), increased CSF total tau (β-coefficient = 0.03, SE = 0.01, p-value = 0.05), and greater volume loss within the entorhinal cortex (β-coefficient = −0.022, SE = 0.005, p-value = 6.30 × 10−6) and hippocampus (β-coefficient = −0.021, SE = 0.005, p-value = 7.86 × 10−5).