On the basis of our regression findings (S1 Appendix Table E), for APOE-e4/e4 homozygotes, the adjusted relative risk for MCI/dementia is 2.7 for NACC, 3.4 for the Framingham Heart Study, and 2.4 for the Rotterdam Study, so disclosing a relative risk of about 3-fold compared to the general population would make sense. This evidence concerns the gene APOE and dementia.