Lifetime incidence rose consistently with APOE-e4 dose: for MCI/dementia (Table 3), it ranged from 11.94%–15.57% for those with no copies of APOE-e4 to 37.47%–46.66% for APOE-e4/e4 homozygote individuals; for dementia alone (Table 5), it ranged from 5.26%–6.83% for no copies to 30.76%–40.26 for homozygote individuals. This evidence concerns the gene APOE and dementia.