APOE and dementia: There was substantially higher risk of MCI/dementia with increasing age (HR 1.08–1.16 per year of age), increasing APOE-e4 dose (for one copy, HR 1.51–2.23; for two copies, HR 2.63–3.57), and lower education (HR 1.41–1.86 for less than high school compared to high school).