POU3F2 and Leukoencephalopathy: In this regard, Pou3f2 could have a role in the human vascular diseases caused by mutations in Notch family members, such as Alagille syndrome and cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) (Loomes et al., 1999; Joutel et al., 1997).