TLR4 and colonic neoplasm: It has been reported that RSV could restrain inflammatory effect in liver of old mice by reducing kinds of proinflammatory cytokines23, alleviate LPS-induced inflammation in Caco-2 and SW480 human colon cancer cells through inhibiting NF-κB pathway24, protect LPS-induced extracellular lipoperoxidation via Myd88-dependent signaling pathway25, mitigate lipopolysaccharide- and Aβ-mediated microglial inflammation by inhibiting the TLR4/NF-κB/STAT signaling cascade12 and modulate the cytokines-stimulated activation of SAPK/JNK pathway in HT-29 human colon cancer cells26.