In the meta-analysis of the effects of individual DPP-4 inhibitors on insulin resistance (Supplementary Figure 6), we observed a significant improvement in insulin resistance with sitagliptin treatment without evidence of significant heterogeneity (WMD −0.38; 95% CI −0.69, −0.08; I2 = 0%, P for heterogeneity = 0.58). Here, DPP4 is linked to Insulin resistance.