Several reports have indicated that clotrimazole has anti-cancer properties by decreasing hexokinase (HK) binding to the outer mitochondrial membrane, detaching phosphofructokinase-1 (PFK-1) and aldolase from the cytoskeleton, and by interfering with Ca2+ metabolism and blockage of the Ca2+ activated potassium channel52, 53, 54, 55, 56. Here, PFKM is linked to cancer.