Besides, some other specific micro-deletions/duplications have also been reported with a discrepant proportion of maternal or paternal origins, such as NF1 region with an excess of maternal deletions18, the ~550 kbp autism-associated region on 16p11.2 with a maternal bias for both de novo deletions and duplications19, Sotos syndrome and 22q13 deletion syndrome with an excess of paternal deletions20, 21, 22, 23. This evidence concerns the gene NF1 and Sotos syndrome.