NF1 and autism: Besides, some other specific micro-deletions/duplications have also been reported with a discrepant proportion of maternal or paternal origins, such as NF1 region with an excess of maternal deletions18, the ~550 kbp autism-associated region on 16p11.2 with a maternal bias for both de novo deletions and duplications19, Sotos syndrome and 22q13 deletion syndrome with an excess of paternal deletions20, 21, 22, 23.