MAPT and early-onset autosomal dominant Alzheimer disease: Indeed, positive 14-3-3 signal can be detected in the CSF of various neurological disorders such as acute stroke, meningoencephalitis, and subarachnoidal haemorrhage [31, 32], while elevated tau is a common hallmark in several types of neurodegenerative dementias (Alzheimer’s disease, mild cognitive impairment, vascular dementia, and fronto-temporal dementia) [29, 33] and in acute ischemic events [34].