TLR9 and thrombophilia: Multivariate Cox regression analyses (adjusted for duration of anticoagulant treatment, mild and severe thrombophilia, location of DVT, family history and acquired risk factors for VTE), showed that female patients with TLR9 rs5743836 polymorphism have significantly higher risk of VTE recurrence as compared to patients with wild-type genotype (HR 3.44, CI 1.05–11.26, P = 0.042) (Table 1 in the Supplementary Appendix).