TP53 and plasma cell myeloma: The work done by Lodè and colleagues showed that TP53 mutations are exclusively associated with del(17p); by sequencing for TP53 gene in 92 newly diagnosed myeloma patients, 37% of 54 patients with del(17p) have mutations of the TP53 gene (63% are homozygous), while none of the patients without del(17p) expressed TP53 mutation [60].