Analysis of cytokine-producing Treg in autoimmune diseases indicated an enrichment of IFNγ+Foxp3+ Treg in patients with type 1 diabetes (16) or multiple sclerosis (17), IL17+Foxp3+CD4+ T cells in patients with ulcerative colitis (18), Crohn’s disease (19) or psoriasis (20), and IFNγ- and IL-17-producing Treg in patients with autoimmune hepatitis (21) compared to healthy individuals. The gene discussed is FOXP3; the disease is Crohn disease.